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Publication

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Gillian Douglas | Vedanta Mehta | Ayman Al Haj Zen | Ioannis Akoumianakis | Anuj Goel | Victoria S Rashbrook | Lucy Trelfa | Lucy Donovan | Edward Drydale | Surawee Chuaiphichai | Charalambos Antoniades | Hugh Watkins | Theodosios Kyriakou | Ellie Tzima | Keith M Channon
Cardiovascular research | 2020

Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which JCAD could influence the development of atherosclerosis.

Pubmed ID: 31584065

Research resources used in this publication

None found

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Antibodies used in this publication

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Associated grants

  • Agency: British Heart Foundation, United Kingdom
    Id: RG/12/5/29576
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/13/56/30383
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/16/29/32128
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/15/35/31403
  • Agency: Medical Research Council, United Kingdom
    Id: G0200482
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/11/66/28855
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/16/15/32047
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/17/10/32859
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/07/003/23133
  • Agency: British Heart Foundation, United Kingdom
    Id: CH/16/1/32013
  • Agency: Wellcome Trust, United Kingdom
    Id: 090532/Z/09/Z
  • Agency: British Heart Foundation, United Kingdom
    Id: RE/13/1/30181
  • Agency: British Heart Foundation, United Kingdom
    Id: RE/18/3/34214
  • Agency: Department of Health, United Kingdom

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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Image Pro Plus (tool)

RRID:SCR_007369

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Software package to capture, process, measure, analyze and share images and data.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6N (tool)

RRID:MGI:2159965

laboratory mouse with name C57BL/6N from MGI.

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