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Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs). Local administration of IFN-α-producing iPSC-pMCs (IFN-α-iPSC-pMCs) alters the tumor microenvironment and propagates the molecular signature associated with type I IFN. The gene-modified cell actively influences host XCR1+ dendritic cells to enhance CD8+ T cell priming, resulting in CXCR3-dependent and STING-IRF3 pathway-independent systemic tumor control. Administration of IFN-α-iPSC-pMCs in combination with immune checkpoint blockade overcomes resistance to single-treatment modalities and generates long-lasting antitumor immunity. These preclinical data suggest that IFN-α-iPSC-pMCs might constitute effective immune-stimulating agents for cancer that are refractory to checkpoint blockade.
Pubmed ID: 31577946
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Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software Python package that provides infrastructure to process data from high-throughput sequencing assays. While the main purpose of HTSeq is to allow you to write your own analysis scripts, customized to your needs, there are also a couple of stand-alone scripts for common tasks that can be used without any Python knowledge.
View all literature mentionsInterferome is a database that provides identification of interferon regulated gene signatures from high-throughput data sets (i.e. microarray, proteomic data etc.). It will also assist in identifying regulatory elements and enable comparison of tissue expression of IRGs in human and mouse. Availability of sequence information from more than 37 species, together with comprehensive annotation will enable comparative genomics and phylogenetic analysis to be performed on these IRGs. Within the database, Type I, II and III IFN regulated genes have been manually curated from more than 28 publicly available microarray datasets. Interferon Regulated Genes (IRGs) were identified from multiple microarray and proteomic experiments where cells were treated with IFNs. Genes that were up or down regulated more than 1.5 fold relative to control samples were defined as IRGs.
View all literature mentionsA high-quality integrated knowledge resource specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrate species, and in the immunoglobulin superfamily (IgSF), MHC superfamily (MhcSF) and related proteins of the immune system (RPI) of vertebrates and invertebrates, serving as the global reference in immunogenetics and immunoinformatics. IMGT provides a common access to sequence, genome and structure Immunogenetics data, based on the concepts of IMGT-ONTOLOGY and on the IMGT Scientific chart rules. IMGT works in close collaboration with EBI (Europe), DDBJ (Japan) and NCBI (USA). IMGT consists of sequence databases, genome database, structure database, and monoclonal antibodies database, Web resources and interactive tools.
View all literature mentionsSoftware tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions.
View all literature mentionsSoftware tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality.
View all literature mentionsConversion software that both demultiplexes data and converts BCL files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis.
View all literature mentionsGraph-based alignment of next generation sequencing reads to a population of genomes.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsSoftware application for performing Gene Ontology analysis on RNAseq data and other length biased data. Used to reduce complexity and highlight biological processes in genome wide expression studies.
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets PD-L1 (B7-H1)
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis unknown targets FITC labeled mouse CD8 monoclonal antibody
View all literature mentionsThis monoclonal targets Perforin
View all literature mentionsThis monoclonal targets CD205
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets Perforin antibody [CB5.4]
View all literature mentionsThis monoclonal targets IFNAR-1
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD169
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets H-2Kb bound to SIINFEKL
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis monoclonal targets CD8α
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets XCR1
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets IFNAR-1
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis isotype control targets KLH
View all literature mentionsCell line RMA-S is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsMus musculus with name B6.Cg-Xcr1tm2(HBEGF/Venus)Ksho from IMSR.
View all literature mentionsCell line MC-38 is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsMus musculus with name B6.Cg-Xcr1tm2(HBEGF/Venus)Ksho from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Xcr1tm2(HBEGF/Venus)Ksho from IMSR.
View all literature mentionsCell line CT26.WT is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line EL4 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentions