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Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease.

Wenqi Diao | Wassim W Labaki | MeiLan K Han | Larisa Yeomans | Yihan Sun | Zyad Smiley | Jae Hyun Kim | Cora McHugh | Pingchao Xiang | Ning Shen | Xiaoyan Sun | Chenxia Guo | Ming Lu | Theodore J Standiford | Bei He | Kathleen A Stringer
International journal of chronic obstructive pulmonary disease | 2019

Chronic obstructive pulmonary disease (COPD) is a systemic condition that is too complex to be assessed by lung function alone. Metabolomics has the potential to help understand the mechanistic underpinnings that contribute to COPD pathogenesis. Since blood metabolomics may be affected by sex and body mass index (BMI), the aim of this study was to determine the metabolomic variability in male smokers with and without COPD who have a narrow BMI range.

Pubmed ID: 31564849

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: K24 HL138188
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM111400
  • Agency: NHLBI NIH HHS, United States
    Id: T32 HL007749

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ClinicalTrials.gov (tool)

RRID:SCR_002309

Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.

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Abcam (tool)

RRID:SCR_012931

A commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.

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Metabolomics Workbench (tool)

RRID:SCR_013794

Repository for metabolomics data and metadata which provides analysis tools and access to various resources. NIH grantees may upload data and general users can search metabolomics database. Provides protocols for sample preparation and analysis, information about NIH Metabolomics Program, data sharing guidelines, funding opportunities, services offered by its Regional Comprehensive Metabolomics Resource Cores (RCMRC)s, and training workshops.

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