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Publication

Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.

Yoshimasa Imoto | Atsushi Kato | Tetsuji Takabayashi | Whitney Stevens | James E Norton | Lydia A Suh | Roderick G Carter | Ava R Weibman | Kathryn E Hulse | Kathleen E Harris | Anju T Peters | Leslie C Grammer | Bruce K Tan | Kevin Welch | Stephanie Shintani-Smith | David B Conley | Robert C Kern | Shigeharu Fujieda | Robert P Schleimer
The Journal of allergy and clinical immunology | 2019

Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease subdivided based on the presence or absence of nasal polyps (NPs). Histologic features of chronic rhinosinusitis with nasal polyps (CRSwNP) include inflammatory cell infiltration and excessive fibrin deposition in NPs. Thrombin-activatable fibrinolysis inhibitor (TAFI) is an enzyme that plays an antifibrinolytic role in the body. The significance of TAFI has been documented in patients with chronic inflammatory diseases, including chronic lung disease; however, it has not been evaluated in the pathogenesis of NPs.

Pubmed ID: 31562871

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: P01 AI145818
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI137174
  • Agency: NHLBI NIH HHS, United States
    Id: R37 HL068546
  • Agency: NIAID NIH HHS, United States
    Id: U19 AI106683

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