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Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.

Sneha Sant | Misty R Jenkins | Pradyot Dash | Katherine A Watson | Zhongfang Wang | Angela Pizzolla | Marios Koutsakos | Thi Ho Nguyen | Martha Lappas | Jane Crowe | Tom Loudovaris | Stuart I Mannering | Glen P Westall | Tom C Kotsimbos | Allen C Cheng | Linda Wakim | Peter C Doherty | Paul G Thomas | Liyen Loh | Katherine Kedzierska
Clinical & translational immunology | 2019

Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T-cell receptor (TCR) clonal expansions. We dissected anti-viral functions of human γδ T cells towards influenza viruses and defined influenza-reactive γδ TCRs in the context of γδ-TCRs across the human lifespan.

Pubmed ID: 31559018

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI121832

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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RRID:SCR_006802

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RRID:SCR_008520

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BD Biosciences (tool)

RRID:SCR_013311

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A-549 (tool)

RRID:CVCL_0023

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