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Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?

Viola Pongratz | Paul Schmidt | Matthias Bussas | Sophia Grahl | Christian Gaser | Achim Berthele | Muna-Miriam Hoshi | Jan Kirschke | Claus Zimmer | Bernhard Hemmer | Mark Mühlau
Brain and behavior | 2019

New or enlarging T2-hyperintense white matter lesions (WML) are associated with clinical disease progression in multiple sclerosis (MS). The prognostic value of WML shrinking is unclear. Assuming that waning of acute inflammation and repair processes would be the main drivers of WML shrinking, we aimed to assess the prognostic value of WML shrinking in early MS.

Pubmed ID: 31557419

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SPM (tool)

RRID:SCR_007037

Software package for analysis of brain imaging data sequences. Sequences can be a series of images from different cohorts, or time-series from same subject. Current release is designed for analysis of fMRI, PET, SPECT, EEG and MEG.

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