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Modulation of osmotic stress-induced TRPV1 expression rescues human iPSC-derived retinal ganglion cells through PKA.

Chih-Chien Hsu | Ke-Hung Chien | Aliaksandr A Yarmishyn | Waradee Buddhakosai | Wen-Ju Wu | Tai-Chi Lin | Shih-Hwa Chiou | Jiann-Torng Chen | Chi-Hsien Peng | De-Kuang Hwang | Shih-Jen Chen | Yuh-Lih Chang
Stem cell research & therapy | 2019

Transient receptor potential vanilloid 1 (TRPV1), recognized as a hyperosmolarity sensor, is a crucial ion channel involved in the pathogenesis of neural and glial signaling. Recently, TRPV1 was determined to play a role in retinal physiology and visual transmission. In this study, we sought to clarify the role of TRPV1 and the downstream pathway in the osmotic stress-related retina ganglion cell (RGC) damage.

Pubmed ID: 31547874

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

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SPSS (tool)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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RRID:SCR_008452

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Millipore (tool)

RRID:SCR_008983

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pClamp (tool)

RRID:SCR_011323

Software suite for electrophysiology data acquisition and analysis by Molecular Devices. Used for the control and recording of voltage clamp, current clamp, and patch clamp experiments. The software suite consists of Clampex 11 Software for data acquisition, AxoScope 11 Software for background recording, Clampfit 11 Software for data analysis, and optional Clampfit Advanced Analysis Module for sophisticated and streamlined analysis.

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Abcam (tool)

RRID:SCR_012931

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