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Publication

Sequential combination of bortezomib and WEE1 inhibitor, MK-1775, induced apoptosis in multiple myeloma cell lines.

Rebecca S S Barbosa | Paola M Dantonio | Taís Guimarães | Mariana B de Oliveira | Veruska L Fook Alves | Alex Freire Sandes | Rodrigo Carlini Fernando | Gisele W B Colleoni
Biochemical and biophysical research communications | 2019

Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. WEE1 is a cell cycle related gene that regulates the G2/M checkpoint and promotes cell cycle suspension for consequent DNA repair. To date, there are clinical studies for the evaluation of WEE1 inhibitors in the treatment of solid tumors and studies on cell lines of non-MM hematological tumors.

Pubmed ID: 31540690

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U266B1 (tool)

RRID:CVCL_0566

Cell line U266B1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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RPMI-8226 (tool)

RRID:CVCL_0014

Cell line RPMI-8226 is a Cancer cell line with a species of origin Homo sapiens (Human)

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