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Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement.

Aya Ogura | Hirohisa Watanabe | Kazuya Kawabata | Reiko Ohdake | Yasuhiro Tanaka | Michihito Masuda | Toshiyasu Kato | Kazunori Imai | Takamasa Yokoi | Kazuhiro Hara | Epifanio Bagarinao | Yuichi Riku | Ryoichi Nakamura | Yoshinari Kawai | Masahiro Nakatochi | Naoki Atsuta | Masahisa Katsuno | Gen Sobue
EBioMedicine | 2019

The clinicopathological continuity between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is well known. Although ALS demonstrates language symptoms similar to FTLD, including semantic dementia, word reading impairments in ALS have not been well studied. "Jukujikun" are Kanji-written words with irregular pronunciation comparable to "exception words" and useful for detecting semantic deficits in Japan. We conducted a cross-sectional study to investigate Jukujikun reading impairments and related network changes in ALS.

Pubmed ID: 31492562

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MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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