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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy.

Peiye Song | Yanru Li | Yuan Dong | Yingying Liang | Huinan Qu | Da Qi | Yan Lu | Xiangshu Jin | Yantong Guo | Yiyang Jia | Xinqi Wang | Wenhong Xu | Chengshi Quan
Journal of experimental & clinical cancer research : CR | 2019

Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear. Claudin-6 (CLDN6), a tight junction protein, acts as a tumor suppressor gene in breast cancer. Our previous studies have found that 17β-estradiol (E2) induces CLDN6 expression and inhibits MCF-7 cell migration and invasion, but the underlying molecular mechanisms are still unclear. In this study, we aimed to investigate the role of ERβ in this process and the regulatory mechanisms involved.

Pubmed ID: 31412908

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