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Publication

B7-H3 participates in human salivary gland epithelial cells apoptosis through NF-κB pathway in primary Sjögren's syndrome.

Ping Li | Ying Yang | Yi Jin | Rui Zhao | Chen Dong | Wenjie Zheng | Tianyi Zhang | Jing Li | Zhifeng Gu
Journal of translational medicine | 2019

Primary Sjögren's syndrome (pSS) is an autoimmune disorder mainly characterized by exocrine gland injury. Costimulatory molecules play an important role in immune-regulatory networks. Although B7 family costimulatory molecules were previously discovered in human salivary gland epithelial (HSGE) cells in pSS, the effects of the B7 family member B7-H3 (CD276) have not been well elucidated. Thus, this study aimed to investigate the role and mechanism of B7-H3 in HSGE cells in pSS.

Pubmed ID: 31412888

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Associated grants

  • Agency: Science and technology Project of Nantong City, International
    Id: MS12017002-4
  • Agency: National Natural Science Foundation of China, International
    Id: 81871278

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