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Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition.

Longzheng Xia | Jingguan Lin | Jian Su | Linda Oyang | Heran Wang | Shiming Tan | Yanyan Tang | Xiaoyan Chen | Wenbin Liu | Xia Luo | Yutong Tian | Jiaxin Liang | Qi Su | Qianjin Liao | Yujuan Zhou
OncoTargets and therapy | 2019

Prevention of epithelial-mesenchymal transition (EMT) provides a novel treatment strategy for tumor metastasis. Our previous studies have shown that diallyl disulfide (DADS) inhibits Ras related C3 botulinum toxin substrate1 (Rac1) expression, being a potential agent that suppresses migration and invasion of colon cancer cells. The study provides information on the underlying mechanisms.

Pubmed ID: 31410018

Research resources used in this publication

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