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T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ·NO/cGMP Signaling.

Rebecca Schüler | Panagiotis Efentakis | Johannes Wild | Jérémy Lagrange | Venkata Garlapati | Michael Molitor | Sabine Kossmann | Matthias Oelze | Paul Stamm | Huige Li | Katrin Schäfer | Thomas Münzel | Andreas Daiber | Ari Waisman | Philip Wenzel | Susanne Helena Karbach
Oxidative medicine and cellular longevity | 2019

The neutrophil recruiting cytokine Interleukin-17A (IL-17A) is a key component in vascular dysfunction and arterial hypertension. Moreover, IL-17A has a central role for the vascular infiltration of myeloid cells into the arterial wall in Angiotensin II-induced vascular inflammation. The intention of our study was to analyze the impact of T cell-derived IL-17A on hypertension, vascular function, and inflammation.

Pubmed ID: 31396305

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GraphPad Prism (tool)

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