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Publication

Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis.

Meghan E Free | Katherine G Stember | Jacob J Hess | Elizabeth A McInnis | Olivier Lardinois | Susan L Hogan | Yichun Hu | Carmen Mendoza | Andrew K Le | Alex J Guseman | Mark A Pilkinton | Dante S Bortone | Kristen Cowens | John Sidney | Edita Karosiene | Bjoern Peters | Eddie James | William W Kwok | Benjamin G Vincent | Simon A Mallal | J Charles Jennette | Dominic J Ciavatta | Ronald J Falk
Journal of autoimmunity | 2020

Treatment of autoimmune diseases has relied on broad immunosuppression. Knowledge of specific interactions between human leukocyte antigen (HLA), the autoantigen, and effector immune cells, provides the foundation for antigen-specific therapies. These studies investigated the role of HLA, specific myeloperoxidase (MPO) epitopes, CD4+ T cells, and ANCA specificity in shaping the immune response in patients with anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis.

Pubmed ID: 31383567

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: T32 DK007750
  • Agency: NIDDK NIH HHS, United States
    Id: P01 DK058335
  • Agency: NCATS NIH HHS, United States
    Id: TL1 TR001110
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK125350
  • Agency: NCI NIH HHS, United States
    Id: P30 CA016086

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RRID:SCR_027363

Software tool as comprehensive analysis framework for T-cell and B-cell repertoire sequencing data.

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