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RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling.

Fan Dai | Yan Qi | Wei Guan | Guoliang Meng | Zhaoguo Liu | Ting Zhang | Wenjuan Yao
Atherosclerosis | 2019

The physiological role of Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) in vascular remodeling remains unknown. We investigated the function of RhoGDI in angiotensin II (Ang II)-induced vascular remodeling in cultured human aortic vascular smooth muscle cells (HA-VSMCs) and in an Ang II-infusion vascular remodeling mouse model.

Pubmed ID: 31362179

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GeneMark (tool)

RRID:SCR_011930

A family of gene prediction programs developed at Georgia Institute of Technology.

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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