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A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival.

Min Jia | Yan Zhang | Lina Jansen | Viola Walter | Dominic Edelmann | Melanie Gündert | Katrin E Tagscherer | Wilfried Roth | Melanie Bewerunge-Hudler | Esther Herpel | Matthias Kloor | Alexis Ulrich | Barbara Burwinkel | Hendrik Bläker | Jenny Chang-Claude | Hermann Brenner | Michael Hoffmeister
Clinical epigenetics | 2019

Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and mostly based on different CIMP definitions. The current study aimed to comprehensively investigate the associations between DNA methylation on genes previously used to define CIMP status with CRC survival.

Pubmed ID: 31340858

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QIAGEN (tool)

RRID:SCR_008539

A commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.

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