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A human subcortical network underlying social avoidance revealed by risky economic choices.

Johannes Schultz | Tom Willems | Maria Gädeke | Ghada Chakkour | Alexander Franke | Bernd Weber | Rene Hurlemann
eLife | 2019

Social interactions have a major impact on well-being. While many individuals actively seek social situations, others avoid them, at great cost to their private and professional life. The neural mechanisms underlying individual differences in social approach or avoidance tendencies are poorly understood. Here we estimated people's subjective value of engaging in a social situation. In each trial, more or less socially anxious participants chose between an interaction with a human partner providing social feedback and a monetary amount. With increasing social anxiety, the subjective value of social engagement decreased; amygdala BOLD response during decision-making and when experiencing social feedback increased; ventral striatum BOLD response to positive social feedback decreased; and connectivity between these regions during decision-making increased. Amygdala response was negatively related to the subjective value of social engagement. These findings suggest a relation between trait social anxiety/social avoidance and activity in a subcortical network during social decision-making.

Pubmed ID: 31329098

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This is a list of tools and resources that we have found mentioned in this publication.


Generalized PPI Toolbox (tool)

RRID:SCR_009489

An automated toolbox for a generalized form of psychophysiological interactions for SPM and FSFAST. The automated toolbox can do the following: (a1) produce identical results to the current implementation in SPM (a2) use the current implementation of PPI in SPM but using the regional mean instead of the eigenvariate (a3) use a generalized form that allows a PPI for each task to be in the same model using either the regional mean of eigenvariate (b) create the model using the output of one of the (a) options and the first level design (c) estimate the model (/results directory) (d) compute the contrasts specified.

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RRID:SCR_013726

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LIBSVM (software resource)

RRID:SCR_010243

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MATLAB (software resource)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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LIBSVM (software resource)

RRID:SCR_010243

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RRID:SCR_015823

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JASP (software resource)

RRID:SCR_015823

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MATLAB (software resource)

RRID:SCR_001622

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RRID:SCR_007378

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SPM (software resource)

RRID:SCR_007037

Software package for analysis of brain imaging data sequences. Sequences can be a series of images from different cohorts, or time-series from same subject. Current release is designed for analysis of fMRI, PET, SPECT, EEG and MEG.

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WFU PickAtlas (data processing software)

RRID:SCR_007378

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Psychophysics Toolbox (software resource)

RRID:SCR_002881

A free set of Matlab and GNU/Octave functions for vision research. It makes it easy to synthesize and show accurately controlled visual and auditory stimuli and interact with the observer.

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