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Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training-mediated myonuclear accretion and muscle mass gain in rats.

Satoru Ato | Kohei Kido | Koji Sato | Satoshi Fujita
Experimental physiology | 2019

What is the central question of this study? Type 2 diabetes mellitus (T2DM) causes skeletal muscle atrophy; does it affect resistance training (RT)-mediated molecular adaptations and subsequent muscle hypertrophy? What is the main finding and its importance? Although skeletal muscle mass and regulation were not preserved under conditions of T2DM, the response of RT-induced skeletal muscle hypertrophy was not impaired in T2DM rat skeletal muscle. These findings suggest that the capacity of RT-mediated muscle mass gain is not diminished in the T2DM condition.

Pubmed ID: 31328833

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Associated grants

  • Agency: Japan Society for the Promotion of Science, International
    Id: 17H02183
  • Agency: Japanese Council for Science, Technology and Innovation, International
    Id: 14533567
  • Agency: NARO, International

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