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The mechanisms that enable immune evasion at metastatic sites are poorly understood. We show that the Polycomb Repressor Complex 1 (PRC1) drives colonization of the bones and visceral organs in double-negative prostate cancer (DNPC). In vivo genetic screening identifies CCL2 as the top prometastatic gene induced by PRC1. CCL2 governs self-renewal and induces the recruitment of M2-like tumor-associated macrophages and regulatory T cells, thus coordinating metastasis initiation with immune suppression and neoangiogenesis. A catalytic inhibitor of PRC1 cooperates with immune checkpoint therapy to reverse these processes and suppress metastasis in genetically engineered mouse transplantation models of DNPC. These results reveal that PRC1 coordinates stemness with immune evasion and neoangiogenesis and point to the potential clinical utility of targeting PRC1 in DNPC.
Pubmed ID: 31327655
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Portal to interactively visualize genomic data. Provides reference sequences and working draft assemblies for collection of genomes and access to ENCODE and Neanderthal projects. Includes collection of vertebrate and model organism assemblies and annotations, along with suite of tools for viewing, analyzing and downloading data.
View all literature mentionsSoftware tools for Motif Discovery and next-gen sequencing analysis. Used for analyzing ChIP-Seq, GRO-Seq, RNA-Seq, DNase-Seq, Hi-C and numerous other types of functional genomics sequencing data sets. Collection of command line programs for unix style operating systems written in Perl and C++.
View all literature mentionsUltrafast and memory efficient tool for aligning sequencing reads to long reference sequences. Supports gapped, local, and paired end alignment modes. More suited to finding longer, gapped alignments in comparison with original Bowtie method.
View all literature mentionsSoftware tool for versatile matrix visualization and analysis. Program to generate heatmaps from input data. JavaScript matrix visualization and analysis.
View all literature mentionsMus musculus with name NU/J from IMSR.
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis polyclonal targets Histone H3, trimethyl (Lys27)
View all literature mentionsThis recombinant monoclonal targets CD8
View all literature mentionsThis monoclonal targets Phc2
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis polyclonal targets Histone H3, acetyl (Lys27)
View all literature mentionsThis monoclonal targets ARG1
View all literature mentionsThis monoclonal targets Syp
View all literature mentionsThis polyclonal targets iNOS antibody
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis polyclonal targets
View all literature mentionsThis monoclonal targets A suspension of Abelson murine leukemia virus-induced pre-B tumor cells.
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Glucocorticoid Receptor (D8H2) XP Rabbit mAb
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser15)
View all literature mentionsThis monoclonal targets Androgen Receptor (D6F11) XP Rabbit mAb
View all literature mentionsThis polyclonal targets Histone H2A antibody - ChIP Grade
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets Human CD44
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets E-Cadherin (24E10) Rabbit mAb
View all literature mentionsThis recombinant monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets PD-1 (CD279)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets PCGF1
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Vimentin
View all literature mentionsThis recombinant monoclonal targets Ki67
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis polyclonal targets ITGB4
View all literature mentionsThis polyclonal targets Mouse CD4
View all literature mentionsThis polyclonal targets Mouse NKp46 / NCR1
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsCell line DU145 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line VCaP is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsCell line PC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TRAMP-C1 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line 22Rv1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line LNCaP clone FGC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line PC12 is a Cancer cell line with a species of origin Rattus norvegicus
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line Myc-CaP is a Cancer cell line with a species of origin Mus musculus
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