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Resistance of parvalbumin to gastrointestinal digestion is required for profound and long-lasting prophylactic oral tolerance.

Raphaela Freidl | Antonia Gstöttner | Ulrike Baranyi | Ines Swoboda | Frank Stolz | Margarete Focke-Tejkl | Thomas Wekerle | Ronald van Ree | Rudolf Valenta | Birgit Linhart
Allergy | 2020

Early introduction of food allergens into children's diet is considered as a strategy for the prevention of food allergy. The major fish allergen parvalbumin exhibits high stability against gastrointestinal digestion. We investigated whether resistance of carp parvalbumin to digestion affects oral tolerance induction.

Pubmed ID: 31325321

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Associated grants

  • Agency: German Society for Allergology and Clinical Immunology, International
  • Agency: Seventh Framework Programme, International
    Id: 201871 (FAST)
  • Agency: Specific immunotherapy, International
  • Agency: Austrian Science Fund, International
    Id: SFB F4605
  • Agency: Austrian Science Fund FWF, Austria
    Id: F 4605
  • Agency: Austrian Science Fund, International
    Id: P23350-B11

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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