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Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy.

Maria Eduarda Rocha França | Renata Kelly Luna Gomes Ramos | Wilma Helena Oliveira | Eduardo Duarte-Silva | Shyrlene Meyre Rocha Araújo | Deniele Bezerra Lós | Christina Alves Peixoto
Toxicology and applied pharmacology | 2019

Tadalafil displays important neuroprotective effects in experimental models of neurodegenerative diseases, however its mechanisms of action remain poorly understood. The aim of the present study was to investigate the action of Tadalafil on learning and memory, neuroinflammation, glial cell activation and neuroprotection in the experimental model of hepatic encephalopathy (HE) induced by Thioacetamide (TAA) in mice.

Pubmed ID: 31323263

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This is a list of tools and resources that we have found mentioned in this publication.


GNU Image Manipulation Program (tool)

RRID:SCR_003182

A software application for such tasks as photo retouching, image composition and image authoring. It has many capabilities such as it can be used as a simple paint program, an expert quality photo retouching program, an online batch processing system, a mass production image renderer, an image format converter, etc. GIMP is expandable and extensible and designed to be augmented with plug-ins and extensions. The advanced scripting interface allows everything from the simplest task to the most complex image manipulation procedures to be easily scripted.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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