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Publication

The nasal methylome as a biomarker of asthma and airway inflammation in children.

Andres Cardenas | Joanne E Sordillo | Sheryl L Rifas-Shiman | Wonil Chung | Liming Liang | Brent A Coull | Marie-France Hivert | Peggy S Lai | Erick Forno | Juan C Celedón | Augusto A Litonjua | Kasey J Brennan | Dawn L DeMeo | Andrea A Baccarelli | Emily Oken | Diane R Gold
Nature communications | 2019

The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) and lung function. We find multiple differentially methylated CpGs (FDR < 0.05) and Regions (DMRs; ≥ 5-CpGs and FDR < 0.05) for asthma (285-CpGs), FeNO (8,372-CpGs; 191-DMRs), total IgE (3-CpGs; 3-DMRs), environment IgE (17-CpGs; 4-DMRs), allergic asthma (1,235-CpGs; 7-DMRs) and bronchodilator response (130-CpGs). Discovered DMRs annotated to genes implicated in allergic asthma, Th2 activation and eosinophilia (EPX, IL4, IL13) and genes previously associated with asthma and IgE in EWAS of blood (ACOT7, SLC25A25). Asthma, IgE and FeNO were associated with nasal epigenetic age acceleration. The nasal epigenome is a sensitive biomarker of asthma, allergy and airway inflammation.

Pubmed ID: 31300640

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI102960
  • Agency: NHLBI NIH HHS, United States
    Id: R00 HL109162
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL117191
  • Agency: NIEHS NIH HHS, United States
    Id: P30 ES000002
  • Agency: NIH HHS, United States
    Id: UH3 OD023286
  • Agency: U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI), International
    Id: R01HL111108
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL111108
  • Agency: U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS), International
    Id: P30ES000002
  • Agency: U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI), International
    Id: R01HL117191
  • Agency: U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD), International
    Id: MD011764
  • Agency: NIMHD NIH HHS, United States
    Id: R01 MD011764
  • Agency: NIH HHS, United States
    Id: UG3 OD023286
  • Agency: NIEHS NIH HHS, United States
    Id: K23 ES023700
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL132825
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD034568

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