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Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis.

Fabian Glaser | Clara John | Bastian Engel | Benedikt Höh | Sören Weidemann | Jan Dieckhoff | Stephanie Stein | Nathalie Becker | Christian Casar | Fenja Amrei Schuran | Björn Wieschendorf | Max Preti | Friederike Jessen | Andre Franke | Antonella Carambia | Ansgar W Lohse | Harald Ittrich | Johannes Herkel | Joerg Heeren | Christoph Schramm | Dorothee Schwinge
Journal of hepatology | 2019

T cells are central mediators of liver inflammation and represent potential treatment targets in cholestatic liver disease. Whereas emerging evidence shows that bile acids (BAs) affect T cell function, the role of T cells for the regulation of BA metabolism is unknown. In order to understand this interplay, we investigated the influence of T cells on BA metabolism in a novel mouse model of cholangitis.

Pubmed ID: 31207266

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Bio X Cell (tool)

RRID:SCR_004997

Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.

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GENCODE (tool)

RRID:SCR_014966

Human and mouse genome annotation project which aims to identify all gene features in the human genome using computational analysis, manual annotation, and experimental validation.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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