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Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling.

Yongzhi Wang | Feifei Du | Avin Hawez | Matthias Mörgelin | Henrik Thorlacius
British journal of pharmacology | 2019

Recent data suggest that neutrophil extracellular traps (NETs) form aggregates with microparticles (MPs) upon activation of neutrophils although the functional role of NET-MP complexes remain elusive. The objective of this study was to examine the role of NET-MP aggregates in leukocyte recruitment in vivo.

Pubmed ID: 31206609

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