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Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression.

Zhi-Yong Li | LinZhuo Xiao | GuiYing Lin | JuanJuan Tang | YuQiang Chen | Lan Chen | BaoQi Li | MeiLing Wu | ShuYan Liu | ChuQin Huang | Dominique Ferrandon | Zi Li
Parasites & vectors | 2019

Tissue transglutaminase (tTG)-regulating IL-13 plays an important role in the pathogenesis of liver fibrosis resulting from Schistosoma japonicum (Sj) infection. IL-33 and its receptor ST2 are involved in Th2-biased immune responses through the release of IL-5 and IL-13 and subsequent hepatic granuloma pathology induced by Sj infection. However, the relationship between tTG, IL-33/ST2, and liver fibrosis during Schistosoma infection has not been established.

Pubmed ID: 31200771

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