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Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG.

Ana Coito | Silke Biethahn | Janina Tepperberg | Margherita Carboni | Ulrich Roelcke | Margitta Seeck | Pieter van Mierlo | Markus Gschwind | Serge Vulliemoz
Epilepsia open | 2019

Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high-density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low-density clinical electroencephalography (EEG).

Pubmed ID: 31168495

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MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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SPM (tool)

RRID:SCR_007037

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sLORETA (tool)

RRID:SCR_013829

A software application which computes images of electric neuronal activity from EEG and MEG. Standard Low Resolution Brain Electromagnetic Tomography, or sLORETA, localizes “test point sources” exactly (under ideal conditions) when estimating electric neuronal generators. This property can be generalized to any source distribution, based on the principles of linearity and superposition. However, it would be noted that sLORETA has very low spatial resolution.

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