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A high-fat diet induces rapid changes in the mouse hypothalamic proteome.

Fiona H McLean | Fiona M Campbell | Rosamund F Langston | Domenico Sergi | Cibell Resch | Christine Grant | Amanda C Morris | Claus D Mayer | Lynda M Williams
Nutrition & metabolism | 2019

Prolonged over-consumption of a high-fat diet (HFD) commonly leads to obesity and insulin resistance. However, even 3 days of HFD consumption has been linked to inflammation within the key homeostatic brain region, the hypothalamus.

Pubmed ID: 31168311

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