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TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI).

Xing-Liang Yang | Xin Wang | Lin Shao | Guang-Tong Jiang | Jia-Wei Min | Xi-Yu Mei | Xiao-Hua He | Wan-Hong Liu | Wen-Xian Huang | Bi-Wen Peng
Journal of neuroinflammation | 2019

Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and developing countries. Children surviving from HIE often have severe long-term sequela including cerebral palsy, epilepsy, and cognitive disabilities. The severity of HIE in infants is tightly associated with increased IL-1β expression and astrocyte activation which was regulated by transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the TRP family.

Pubmed ID: 31142341

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Thermo Fisher Scientific (tool)

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GraphPad Prism (software resource)

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