Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
Sepsis is a bi-phasic inflammatory disease that threatens approximately 30 million lives and claims over 14 million annually, yet little is known regarding the molecular switches and pathways that regulate this disease. Here, we have described ABCF1, an ATP-Binding Cassette (ABC) family member protein, which possesses an E2 ubiquitin enzyme activity, through which it controls the Lipopolysaccharide (LPS)- Toll-like Receptor-4 (TLR4) mediated gram-negative insult by targeting key proteins for K63-polyubiquitination. Ubiquitination by ABCF1 shifts the inflammatory profile from an early phase MyD88-dependent to a late phase TRIF-dependent signaling pathway, thereby regulating TLR4 endocytosis and modulating macrophage polarization from M1 to M2 phase. Physiologically, ABCF1 regulates the shift from the inflammatory phase of sepsis to the endotoxin tolerance phase, and modulates cytokine storm and interferon-β (IFN-β)-dependent production by the immunotherapeutic mediator, SIRT1. Consequently, ABCF1 controls sepsis induced mortality by repressing hypotension-induced renal circulatory dysfunction.
Pubmed ID: 30770245
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Non-profit plasmid repository dedicated to helping scientists around the world share high-quality plasmids. Facilitates archiving and distributing DNA-based research reagents and associated data to scientists worldwide. Repository contains over 65,000 plasmids, including special collections on CRISPR, fluorescent proteins, and ready-to-use viral preparations. There is no cost for scientists to deposit plasmids, which saves time and money associated with shipping plasmids themselves. All plasmids are fully sequenced for validation and sequencing data is openly available. We handle the appropriate Material Transfer Agreements (MTA) with institutions, facilitating open exchange and offering intellectual property and liability protection for depositing scientists. Furthermore, we curate free educational resources for the scientific community including a blog, eBooks, video protocols, and detailed molecular biology resources.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsCommercial organization which provides life science services and products to researchers. They specialize in gene synthesis, peptide, protein, antibody and preclinical drug development service.
View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
View all literature mentionsThis monoclonal targets Caspase 1 antibody [EPR4321]
View all literature mentionsThis polyclonal targets Human NFkB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb
View all literature mentionsThis monoclonal targets Human SYK
View all literature mentionsThis polyclonal targets PLCG1
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets CD284
View all literature mentionsThis polyclonal targets caspase-1 p10
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis polyclonal targets Myc tag - ChIP Grade
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis monoclonal targets IKB alpha (phospho S32 + S36)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis polyclonal targets Syk (phospho Y525 + Y526)
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis unknown targets ABCF1
View all literature mentionsThis monoclonal targets IKB alpha
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis monoclonal targets CD206
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets PLCG2
View all literature mentionsThis polyclonal targets NFkB p65
View all literature mentionsThis unknown targets mCherry
View all literature mentionsThis monoclonal targets Human TNFAIP3
View all literature mentionsThis polyclonal targets Histone H3 (tri methyl K4)
View all literature mentionsThis polyclonal targets K48-linkage Specific Polyubiquitin
View all literature mentionsThis polyclonal targets ABCF1
View all literature mentionsThis monoclonal targets TAK1 antibody [EPR5984]
View all literature mentionsThis polyclonal targets c-IAP1
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets CD284
View all literature mentionsThis monoclonal targets CD206
View all literature mentions