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Rapid task-dependent tuning of the mouse olfactory bulb.

Anzhelika Koldaeva | Andreas T Schaefer | Izumi Fukunaga
eLife | 2019

Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way.

Pubmed ID: 30724732

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Associated grants

  • Agency: Deutsche Forschungsgemeinschaft, International
    Id: SPP 1392
  • Agency: Wellcome Trust, United Kingdom
    Id: FC001153
  • Agency: Biotechnology and Biological Sciences Research Council, United Kingdom
    Id: BB/E023738/1
  • Agency: Medical Research Council, United Kingdom
    Id: MC_UP_1202/5
  • Agency: Wellcome Trust, United Kingdom
    Id: 110174/Z/15/Z

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MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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Sigma-Aldrich (tool)

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American chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

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