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Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model.

Nayra Cardenes | Paola Aranda-Valderrama | Jonathan P Carney | Jacobo Sellares Torres | Diana Alvarez | Ergin Kocyildirim | Julie A Wolfram Smith | Antony E Ting | Luigi Lagazzi | Zheming Yu | Scott Mason | Ernesto Santos | Brian J Lopresti | Mauricio Rojas
BMJ open respiratory research | 2019

Bone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use in acute respiratory distress syndrome (ARDS). To date, there is no agreement on which is the best method for stem cells delivery in ARDS. Here, we compared the efficacy of two different methods of administration and biodistribution of MAPC for the treatment of ARDS in a sheep model.

Pubmed ID: 30713713

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL123766
  • Agency: NIAAA NIH HHS, United States
    Id: R42 AA024003

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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BD Biosciences (tool)

RRID:SCR_013311

An Antibody supplier

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