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Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study.

Felix Carl Fabian Schmitt | Vasil Manolov | Jakob Morgenstern | Thomas Fleming | Stefan Heitmeier | Florian Uhle | Mohammed Al-Saeedi | Thilo Hackert | Thomas Bruckner | Herbert Schöchl | Markus Alexander Weigand | Stefan Hofer | Thorsten Brenner
Annals of intensive care | 2019

Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shutdown has recently been described to be a crucial component of initial hypercoagulability in critically ill patients, although the underlying pathomechanisms, the specific temporal kinetics and its outcome relevance in patients with sepsis remain to be determined.

Pubmed ID: 30701381

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RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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