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Publication

cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.

Chung-Ming Tse | Jianyi Yin | Varsha Singh | Rafiquel Sarker | Ruxian Lin | Alan S Verkman | Jerrold R Turner | Mark Donowitz
Cellular and molecular gastroenterology and hepatology | 2019

SLC26A3 (DRA) is an electroneutral Cl-/HCO3- exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute adenosine 3',5'-cyclic monophosphate (cAMP)-related diarrheas, in which DRA appears to be both inhibited as part of NaCl absorption and stimulated to contribute to increased HCO3- secretion. Different cell models expressing DRA have shown that cAMP inhibits, stimulates, or does not affect its activity.

Pubmed ID: 30659943

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None found

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R24 DK099803
  • Agency: NIDDK NIH HHS, United States
    Id: P01 DK072084
  • Agency: NIDDK NIH HHS, United States
    Id: R24 DK064388
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK061931
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR000003
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK068271
  • Agency: NCATS NIH HHS, United States
    Id: U18 TR000552
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK116352
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK089502
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK061765
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK034854
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK026523

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Origin (tool)

RRID:SCR_014212

Software application for data analysis and graphing. Origin contains a variety of different graph types, including statistical plots, 2D and 3D vector graphs, and counter graphs. More advance version is OriginPro which offers advanced analysis tools and Apps for Peak Fitting, Surface Fitting, Statistics and Signal Processing.

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RRID:CVCL_0025

Cell line Caco-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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