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Publication

Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells.

Locke D Uppendahl | Martin Felices | Laura Bendzick | Caitlin Ryan | Behiye Kodal | Peter Hinderlie | Kristin L M Boylan | Amy P N Skubitz | Jeffrey S Miller | Melissa A Geller
Gynecologic oncology | 2019

Natural killer (NK) cells are lymphocytes well suited for adoptive immunotherapy. Attempts with adoptive NK cell immunotherapy against ovarian cancer have proven unsuccessful, with the main limitations including failure to expand and diminished effector function. We investigated if incubation of NK cells with interleukin (IL)-12, IL-15, and IL-18 for 16h could produce cytokine-induced memory-like (CIML) NK cells capable of enhanced function against ovarian cancer.

Pubmed ID: 30658847

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA077598
  • Agency: NCI NIH HHS, United States
    Id: P01 CA065493
  • Agency: NCI NIH HHS, United States
    Id: R21 CA150085
  • Agency: NCI NIH HHS, United States
    Id: R35 CA197292
  • Agency: NCI NIH HHS, United States
    Id: P01 CA111412
  • Agency: NCI NIH HHS, United States
    Id: P50 CA136393

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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