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The vaccine adjuvant MPLA activates glycolytic metabolism in mouse mDC by a JNK-dependent activation of mTOR-signaling.

Frank Blanco-Pérez | Alexandra Goretzki | Sonja Wolfheimer | Stefan Schülke
Molecular immunology | 2019

The detoxified TLR4-ligand MPLA is a successfully used adjuvant in clinically approved vaccines. However, its capacity to activate glycolytic metabolism in mDC and the influence of MPLA-induced metabolic changes on cytokine secretion are unknown.

Pubmed ID: 30623816

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PeproTech (tool)

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FlowJo (tool)

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Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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