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Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α.

Yuta Kasagi | Kara Dods | Joshua X Wang | Prasanna M Chandramouleeswaran | Alain J Benitez | Fiona Gambanga | Jonathan Kluger | Tokunbo Ashorobi | Jonathan Gross | John W Tobias | Andres J Klein-Szanto | Jonathan M Spergel | Antonella Cianferoni | Gary W Falk | Kelly A Whelan | Hiroshi Nakagawa | Amanda B Muir
The Journal of allergy and clinical immunology | 2019

Fibrosis and stricture are major comorbidities in patients with eosinophilic esophagitis (EoE). Lysyl oxidase (LOX), a collagen cross-linking enzyme, has not been investigated in the context of EoE.

Pubmed ID: 30578874

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: K01 DK103953
  • Agency: NIDDK NIH HHS, United States
    Id: R03 DK118310
  • Agency: NIDDK NIH HHS, United States
    Id: R03 DK118304
  • Agency: NIAID NIH HHS, United States
    Id: U54 AI117804
  • Agency: NIEHS NIH HHS, United States
    Id: P30 ES013508
  • Agency: NCI NIH HHS, United States
    Id: P01 CA098101
  • Agency: NIDDK NIH HHS, United States
    Id: K08 DK106444
  • Agency: NIDDK NIH HHS, United States
    Id: F32 DK100088
  • Agency: NCI NIH HHS, United States
    Id: F31 CA174176
  • Agency: NCATS NIH HHS, United States
    Id: KL2 TR001879
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK050306
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK114436

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