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Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice.

Wang Jin | Xiaowen Liang | Anastasia Brooks | Kathryn Futrega | Xin Liu | Michael R Doran | Matthew J Simpson | Michael S Roberts | Haolu Wang
PeerJ | 2018

Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to sites of injury. However in vivo MSC distribution following intravenous transplantation remains poorly understood, potentially hampering the precise prediction and evaluation of therapeutic efficacy.

Pubmed ID: 30564525

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