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FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating function of FGD4. Expression of FGD4 is altered in patients with heterogeneous hereditary motor and sensory neuropathies as a result of demyelination of peripheral nerves.
Pubmed ID: 30558664
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View all literature mentionsCell line LNCaP is a Cancer cell line with a species of origin Homo sapiens (Human)
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