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CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers.

Vasiliki Pelekanou | Franz Villarroel-Espindola | Kurt A Schalper | Lajos Pusztai | David L Rimm
Breast cancer research : BCR | 2018

The role of tumor-associated macrophages (TAMs) in the cancer immune landscape and their potential as treatment targets or modulators of response to treatment are gaining increasing interest. TAMs display high molecular and functional complexity. Therefore their objective assessment as breast cancer biomarkers is critical. The aims of this study were to objectively determine the in situ expression and significance of TAM biomarkers (CD68, CD163, and MMP-9) in breast cancer and to identify subclasses of patients who could benefit from TAM-targeting therapies.

Pubmed ID: 30558648

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA016359
  • Agency: NCI NIH HHS, United States
    Id: P50 CA196530
  • Agency: NCI NIH HHS, United States
    Id: P30CA016359

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