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Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia.

Haiyan Zhao | Yaping Zhao | Xin Li | Leiqian Xu | Fangxin Jiang | Wanju Hou | Lixia Dong | Jie Cao
Yonsei medical journal | 2018

Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however, underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS can lead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the intervention effects of antioxidant tempol.

Pubmed ID: 30328323

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Associated grants

  • Agency: National Research Foundation of Korea,
    Id: 8167010263
  • Agency: National Research Foundation of Korea,
    Id: 81400063

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This is a list of tools and resources that we have found mentioned in this publication.


WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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