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Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Åsa Sandelius | Erik Portelius | Åsa Källén | Henrik Zetterberg | Uros Rot | Bob Olsson | Jon B Toledo | Leslie M Shaw | Virginia M Y Lee | David J Irwin | Murray Grossman | Daniel Weintraub | Alice Chen-Plotkin | David A Wolk | Leo McCluskey | Lauren Elman | Vesna Kostanjevecki | Manu Vandijck | Jennifer McBride | John Q Trojanowski | Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association | 2019

The level of the presynaptic protein growth-associated protein 43 (GAP-43) in cerebrospinal fluid (CSF) has previously been shown to be increased in Alzheimer's disease (AD) and thus may serve as an outcome measure in clinical trials and facilitate earlier disease detection.

Pubmed ID: 30321501

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: P01 AG017586
  • Agency: NIA NIH HHS, United States
    Id: P30 AG010124
  • Agency: NINDS NIH HHS, United States
    Id: P50 NS053488
  • Agency: NINDS NIH HHS, United States
    Id: U01 NS097056

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ADNI - Alzheimer's Disease Neuroimaging Initiative (tool)

RRID:SCR_003007

Database of the results of the ADNI study. ADNI is an initiative to develop biomarker-based methods to detect and track the progression of Alzheimer's disease (AD) that provides access to qualified scientists to their database of imaging, clinical, genomic, and biomarker data.

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