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The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.

Ju-Young Lee | Jin Han Nam | Youngpyo Nam | Hye Yeon Nam | Gwangho Yoon | Eunhwa Ko | Sang-Bum Kim | Mahealani R Bautista | Christina C Capule | Takaoki Koyanagi | Geoffray Leriche | Hwan Geun Choi | Jerry Yang | Jeongyeon Kim | Hyang-Sook Hoe
Journal of neuroinflammation | 2018

Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer's disease (AD). Thus, modulating the neuroinflammatory response represents a potential therapeutic strategy for treating neurodegenerative diseases. Several recent studies have shown that dopamine (DA) and its receptors are expressed in immune cells and are involved in the neuroinflammatory response. Thus, we recently developed and synthesized a non-self-polymerizing analog of DA (CA140) and examined the effect of CA140 on neuroinflammation.

Pubmed ID: 30309372

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: R01 AG053577

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