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During neural development, self-avoidance ensures that a neuron's processes arborize to evenly fill a particular spatial domain. At the individual cell level, self-avoidance is promoted by genes encoding cell-surface molecules capable of generating thousands of diverse isoforms, such as Dscam1 (Down syndrome cell adhesion molecule 1) in Drosophila Isoform choice differs between neighboring cells, allowing neurons to distinguish "self" from "nonself". In the mouse retina, Dscam promotes self-avoidance at the level of cell types, but without extreme isoform diversity. Therefore, we hypothesize that DSCAM is a general self-avoidance cue that "masks" other cell type-specific adhesion systems to prevent overly exuberant adhesion. Here, we provide in vivo and in vitro evidence that DSCAM masks the functions of members of the cadherin superfamily, supporting this hypothesis. Thus, unlike the isoform-rich molecules tasked with self-avoidance at the individual cell level, here the diversity resides on the adhesive side, positioning DSCAM as a generalized modulator of cell adhesion during neural development.
Pubmed ID: 30297418
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This monoclonal targets FLAG
View all literature mentionsThis unknown targets mCherry
View all literature mentionsThis polyclonal targets Beta-Gal (Beta-Galactosidase, LacZ)
View all literature mentionsThis monoclonal targets Human Cadherin-6
View all literature mentionsThis polyclonal targets Green Fluorescent Protein
View all literature mentionsThis polyclonal targets NrCAM - Neuronal Marker
View all literature mentionsThis polyclonal secondary targets IgG Fc
View all literature mentionsThis unknown targets Rabbit Mouse Melanopsin Saporin
View all literature mentionsMus musculus with name B6.129S6-Cdh6tm1Sma/J from IMSR.
View all literature mentionsAllele Detail: Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name B6.129S7-Pcdhgtm2Xzw/J from IMSR.
View all literature mentions