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TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice.

Zhen Wang | Yao Xu | Menglong Wang | Jing Ye | Jianfang Liu | Huimin Jiang | Di Ye | Jun Wan
EBioMedicine | 2018

Recent evidence has indicated that the transient receptor potential ankyrin 1 (TRPA1) is expressed in the cardiovascular system and implicated in the development and progression of several cardiovascular diseases. However, the effects of TRPA1 on cardiac hypertrophy development remain unclear. The aim of this study was to determine the role of TRPA1 in cardiac hypertrophy and fibrosis development.

Pubmed ID: 30297144

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