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Publication

Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway.

Rongfeng Yang | Wu Fang | Jiawen Liang | Chao Lin | Shaoyun Wu | Shaodi Yan | Chengheng Hu | Xiao Ke
Archives of medical science : AMS | 2018

Previous studies have shown that endothelial cell senescence is involved in cardiovascular diseases such as cardiac fibrosis, atherosclerosis and heart failure. Accumulating evidence indicates that apelin exerts protective effects on ageing-related endothelial dysfunction. In this study, we aim to investigate the role of the apelin/APJ axis in angiotensin II (AngII)-induced endothelium senescence and its associated mechanisms.

Pubmed ID: 30002688

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