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The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation.

Zengli Zhang | Pei Qin | Youliang Deng | Zhi Ma | Hang Guo | Haiyun Guo | Yushu Hou | Shiquan Wang | Wangyuan Zou | Yanyuan Sun | Yulong Ma | Wugang Hou
Journal of neuroinflammation | 2018

The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating estrogen receptors. The novel estrogen receptor G protein-coupled receptor 30 (GPR30) is highly expressed in the brain and provides acute neuroprotection against stroke. However, the underlying mechanisms remain unclear.

Pubmed ID: 30001721

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RRID:SCR_005057

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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