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The effects of inhaled multi-walled carbon nanotubes on blood pressure and cardiac function.

Wen Zheng | Walter McKinney | Michael L Kashon | Daniel Pan | Vincent Castranova | Hong Kan
Nanoscale research letters | 2018

Heart rate variability (HRV) as a marker reflects the activity of the autonomic nervous system. The prognostic significance of HRV for cardiovascular disease has been reported in clinical and epidemiological studies. Our laboratory has reported alterations in rat heart rate variability (HRV) due to increasing activity of both sympathetic and parasympathetic nervous system after pulmonary exposure to multi-walled carbon nanotubes (MWCNTs). This suggests that pulmonary inhalation of engineered nanoparticles (ENs) may lead to functional changes in the cardiovascular system. The present study further investigated the effects of inhaled MWCNTs on the cardiovascular system and evaluated the correlation between the alterations in HRV and changes in cardiovascular function.

Pubmed ID: 29971611

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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