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Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths.

Hamdi Eryilmaz | Kevin F Dowling | Franklin C Huntington | Anais Rodriguez-Thompson | Thomas W Soare | Lauren M Beard | Hang Lee | Jeffrey C Blossom | Randy L Gollub | Ezra Susser | Ruben C Gur | Monica E Calkins | Raquel E Gur | Theodore D Satterthwaite | Joshua L Roffman
JAMA psychiatry | 2018

Presently, 81 countries mandate the fortification of grain products with folic acid to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on severe mental illness suggest potentially broader effects of prenatal folate exposure on postnatal brain development, but this link remains unsubstantiated by biological evidence.

Pubmed ID: 29971329

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

None found

Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: R01 MH101425
  • Agency: NIMH NIH HHS, United States
    Id: RC2 MH089983
  • Agency: NIMH NIH HHS, United States
    Id: RC2 MH089924
  • Agency: NIMH NIH HHS, United States
    Id: R01 MH107703
  • Agency: NIMH NIH HHS, United States
    Id: R01 MH107235

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This is a list of tools and resources that we have found mentioned in this publication.


FreeSurfer (tool)

RRID:SCR_001847

Open source software suite for processing and analyzing human brain MRI images. Used for reconstruction of brain cortical surface from structural MRI data, and overlay of functional MRI data onto reconstructed surface. Contains automatic structural imaging stream for processing cross sectional and longitudinal data. Provides anatomical analysis tools, including: representation of cortical surface between white and gray matter, representation of the pial surface, segmentation of white matter from rest of brain, skull stripping, B1 bias field correction, nonlinear registration of cortical surface of individual with stereotaxic atlas, labeling of regions of cortical surface, statistical analysis of group morphometry differences, and labeling of subcortical brain structures.Operating System: Linux, macOS.

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MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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