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Role of accelerated aging in limb muscle wasting of patients with COPD.

Ramzi Lakhdar | Dagmara McGuinness | Ellen M Drost | Paul G Shiels | Ricardo Bastos | William MacNee | Roberto A Rabinovich
International journal of chronic obstructive pulmonary disease | 2018

Skeletal muscle wasting is an independent predictor of health-related quality of life and survival in patients with COPD, but the complexity of molecular mechanisms associated with this process has not been fully elucidated. We aimed to determine whether an impaired ability to repair DNA damage contributes to muscle wasting and the accelerated aging phenotype in patients with COPD.

Pubmed ID: 29970961

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