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Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect.

Rudra Pangeni | Jeong Uk Choi | Vijay Kumar Panthi | Youngro Byun | Jin Woo Park
International journal of nanomedicine | 2018

The current study sought to design an oral delivery system of pemetrexed (PMX), a multitargeted antifolate antimetabolite, by enhancing its intestinal membrane permeability.

Pubmed ID: 29922055

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